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This may result in inadequacies, which, in turn, can contribute to age-related illnesses such as cognitive decline and osteoporosis

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Second-line treatments, known as device-aided therapies (DATs), have been developed for LDRCs, such as continuous subcutaneous apomorphine infusion (CSAI), continuous subcutaneous foslevodopa–foscarbidopa, infusion of levodopa–carbidopa intestinal gel (LCIG ± entacapone) and subthalamic deep brain stimulation