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Furthermore, hypoxia can have proliferative effects on human fibroid cells by inducing the expression of NADPH oxidase 4 (NOX4) through the HIF-1α/TGF-β3/Smad3/NOX4 signaling pathway, wherein the phosphorylation of Smad3 by TGF-β3 under hypoxic conditions leads to cellular proliferation and fibroid growth (Figure 2) [8]
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