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Similarly, the epigenetic alterations observed in HGPS, including loss of heterochromatin and aberrant histone modifications, likely impair the circadian regulation of chromatin accessibility and gene expression (Oh et al., 2019)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 23.Raftos J.E., Whillier S., Chapman B.E., Kuchel P.W