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Keywords: ALS, copper, protein, aggregate, TDP-43, SOD1, C9ORF72, neurodegeneration Introduction Amyotrophic Lateral Sclerosis (ALS) is a heterogeneous neurodegenerative disease that primarily affects both upper and lower motor neurons, leading to their progressive degeneration and subsequent, often rapid loss of motor function and death (Brotman et al., 2022)
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