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Key items to verify: Certificate of Analysis (COA): Independent laboratory documentation confirming peptide identity, molecular weight, purity percentage, and absence of contaminants Purity percentage: Research-grade peptides typically require 98% purity or higher Contamination screening: Testing for heavy metals, bacterial endotoxins, and residual solvents Batch-specific COAs from third-party analytical laboratories are the standard

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In preclinical studies of COX-2 selective inhibitors, suppression of PGE2 at the inflammatory site with no change in serum TXB2 confirms COX-2 selectivity, while suppression of both indicates non-selective COX inhibition