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Regular municipal or bottled drinking water generally falls within a near neutral pH range of 6.5 to 8.5, contains low total dissolved solids below 500 mg/L, and primarily functions to maintain hydration and thermoregulation (17, 18)

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These genes may be downregulated by inhibition of the cAMP-mediated pathway and an increase in iROS, which could be linked to a reduction in melanin synthesis in mouse B16 melanoma cells