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Reduced HDL-PON1 levels are also found in other cardiometabolic diseases, including type 2 diabetic mellitus (T2DM) (866,867), type 1 diabetes mellitus (T1DM) (868), rheumatoid arthritis (RA) (869,870), dyslipidemia (e.g
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The study suggests Polyscias fulva may exert its effects by regulating the HIF1A , ESR1 , EGFR , and CASP3 genes, promoting caspase-3 expression, and suppressing HIF-1α, ERα, and EGFR expression [135]
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