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Moreover, the disease course in animal models progresses much faster than human natural ageing, which may exaggerate drug efficacy or obscure long-term adverse effects

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[97] demonstrated that in spontaneously hypertensive rats with a high risk of stroke, supplementation with AST or vitamin E reduced systolic blood pressure, delayed cerebral vascular thrombosis, increased the nitric oxide (NO) metabolic rate, elevated urinary NO₂/NO₃ levels, and significantly decreased 8-OHdG levels