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Case reports and expert consensus instead highlight that tirzepatide alone achieves superior long-term weight loss (average 22 pounds at 21 weeks in STEP trials) without the tolerance decay that limits phentermine to 12 weeks of use

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They are cast as superior to growth hormone injections, which are accompanied by a laundry list of potential side effects including fluid retention and carpal tunnel syndrome, because you are not adding synthetic growth hormone to your body