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Research highlights ↑ NAD+ Increased cellular NAD+ via nicotinamide pool ↓ NNMT Enzyme overexpressed in obese adipose tissue Anti-adip Reduced lipid accumulation and adipocyte differentiation SIRT1 Downstream sirtuin activation via NAD+ elevation Research notes Adipocyte research: In vitro models show reduced lipid accumulation and pre-adipocyte differentiation upon NNMT inhibition

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Multiple mechanisms for laminopathies have been proposed, including impaired structural nuclear and cellular integrity resulting in increased fragility, aberrant gene expression, defective DNA repair, and prelamin A toxicity 9