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In tumor-microenvironment models such as glioma co-culture, mitochondrial membrane potential, enzymatic activity, and ATP synthesis decline, while extracellular lactate production increases, indicating a metabolic shift from oxidative phosphorylation toward aerobic glycolysis (217)

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[DOI] [PubMed] [Google Scholar] 30.Bammens B., Evenepoel P., Keuleers H., Verbeke K., Vanrenterghem Y