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There's a lot of evidence that in Alzheimer's, Parkinson's, definitely stroke, traumatic brain injury, ALS, all of those excitotoxicity is a factor that is neurons continuing to be excited by glutamate when they're in a compromised state, energetically, for example, with a stroke, or we think more subtly in Parkinson's or Alzheimer's, where there's mitochondrial dysfunction that's occurring

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doi: 10.1126/sciadv.ade6790 111 KanekoMKSuzukiHKatoY