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A preliminary study showed that dietary supplementation with α -tocopherol delays the onset of clinical disease and slows progression in transgenic mice that express mutated copies of the gene encoding SOD1 [120]

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Another mechanism proposed is called as floodgate model in which oxidation causes inactivation of the ROS-scavenging enzymes by hyperoxidation or phosphorylation causing localized increases in H 2 O 2 leading to protein oxidation