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Early studies in vivo on transport across the BBB revealed that neutral AA moved from blood to brain by facilitative Na + -independent transport by means of a transmembrane transporter known as LAT1 (from system L amino acid transporter) ( slc7a5 gene and forms a heterodimeric complex with the glycoprotein 4F2hc (CD98, SLC3A2) associated by a disulfide bridge

Caution is advised for pregnant or lactating women