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However, adding certain groups (nitro, methyl, and chloro) into the N-phenyl ring led to more active compounds in the maximal electroshock seizure test compared to the derivatives that are unsubstituted

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Role of the Nrf2 pathway and ferroptosis in lung cancer Keap1-Nrf2-FSP1-mediated ferroptosis in lung cancer Studies on non-small cell lung cancer (NSCLC), both preclinical and clinical, have demonstrated tight relationships among the resistance to chemotherapy, radiation therapy, and other agents, and the loss of function of Keap1 and overexpression of Nrf2