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Depletion of this cellular reservoir of GSH leads to the amplification of oxidative and nitrosative cell damage, hypernitrosylation, increased levels of inflammation, disturbances in intracellular signaling pathways for p53, Janus kinases (JAK), and nuclear factor-κB (NF-κB)

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Phase 5 Gets the Attention It Deserves Most patients focus on the VLCD phase