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Gut microbe-derived metabolites such as ROS and lipopolysaccharides can leak into the body circulation via a bidirectional microbe-gut-brain axis communication system, and these neurotoxin releases from the gut microbiota can elicit an inflammatory response and cross the blood–brain barrier to modulate neuronal activity, and neuroinflammation has been implicated in the pathogenesis of diabetes mellitus and its associated cognitive dysfunction (124)

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Validation lets the patient know that the nurse has heard and understands what was said, promoting the nurse-patient relationship