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The specific issue could be a strong effect on increasing angiogenesis, increased VEGF, increased egr-1 gene, increased NO or eNOS stimulation, and increased free radical formation, interaction with multiple systems, and unescapable risks of unanticipated adverse effects due to pleiotropic effects

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The distal 2–3 mm common peroneal nerve and tibial nerve were tightly ligated, and then sectioned with micro-scissors approximately 5 mm away from the ligation

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