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The results of this study revealed a better therapeutic efficacy for arbutin-loaded chitosan nanoparticles in terms of reduction in MASI score and reduction in epidermal melanin particle size surface area (MPSA) in comparison to the free drug (Hatem et al., 2022)

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In this review, we discuss the physiological functions of human AKRs, the aberrant expression of AKRs in malignancies, the involvement of AKRs in the acquisition of cancer hallmarks, and the role of AKRs in oncogenic signaling, and drug resistance