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As the activation of CD8+ T cells by the anti-PD1 treatment results in the upregulation of CD38, these reinvigorated cells become an immediate target for Daratumumab-mediated lysis, thus abrogating the effectiveness of anti-PD1 treatment
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At the end of the pregnancy the fetus receives some immunoglobulins via plancenta against the most common pathogens the mother experiences, but this first immunization doesn’t last too long
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