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(as long as the causative factor for B 12 deficiency persists, therapy should be continued) Evidence from animal and human studies shows that B 12 also has neuroprotective and anti-inflammatory properties, 15 and intervention studies in humans have reported beneficial effects of better B 12 status or B 12 therapy in multiple sclerosis, 16 Parkinson’s disease, 17 myalgic encephalomyelitis, 18 autism, 19 and (administering very high doses of methylcobalamin) in amyotrophic lateral sclerosis

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Rodent studies show no acute toxicity at doses up to 10× the effective range, but chronic use beyond 12 weeks has not been systematically studied