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Inhibition of SREBP-1 and Fatty Acid Synthase (FAS) increases ATGL and hormone-sensitive lipase protein expression levels, promoting AMPK phosphorylation to attenuate ectopic lipid deposition in renal tubules, improving PA-induced lipid accumulation in renal tubular epithelial cells, inhibiting lipid synthesis, and promoting lipolysis (188)
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[DOI] [PMC free article] [PubMed] [Google Scholar] Robida-Stubbs S, Glover-Cutter K, Lamming DW, Mizunuma M, Narasimhan SD, Neumann-Haefelin E, Sabatini DM, Blackwell TK
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