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The proteasome is part of the ubiquitin proteasome system (UPS), which is critical for protein quality control and is the main intracellular degradation pathway that eliminates polyubiquitinated misfolded and oxidized proteins by a multi-complex 26 S proteasome 16,17,24,40
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A study calculated the frequencies of mutation sites to design a novel antigen Span that encompasses high-frequency mutations
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