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To measure transcriptional relatedness between matched HCMI model–tumour pairs, we used the Celligner distances, which represent the Euclidean distance between a model and its paired tumour in 70-PC space
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But of course, periods of time like after a new child or a new job or a particularly stressful time— I don’t know any human being, I don’t care how driven— okay, there’s probably David Goggins and Cam Haines being probably exceptions and a few others, I don’t want to forget Ken Rideout and a few others— but people who, everybody else seems to have periods of time where they need to just back off a bit
