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The bacteria that make vitamin B12 are active after the ileum, so the B12 can’t be absorbed and used by the body

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[DOI] [PMC free article] [PubMed] [Google Scholar] [69].Bruno BJ, Miller GD, Lim CS, Basics and recent advances in peptide and protein drug delivery, Therapeutic Delivery, 4 (2013) 1443–1467