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Low concentrations of iron ions promote the growth of osteoblast precursor cells (MC3T3-E1), while high concentrations of iron ions inhibit their growth and increase ROS levels

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Yes, the N-terminal hexanoyl cap and specific hydrophobic amino acid sequence (Tyr-Ile-Ahx) were engineered specifically to increase lipophilicity and metabolic stability, allowing Dihexa to cross cell membranes and the blood-brain barrier intact in preclinical models