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132 NakagawaT.ShimizuS.WatanabeT.YamaguchiO.OtsuK.YamagataH.et al (2005)
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It directly stimulates anorexigenic POMC neurons and inhibits adjacent orexigenic NPY neurons in the ARC of the hypothalamus, thus promoting satiety, increasing energy expenditure, and resulting in weight loss (6)
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