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In contrast, JNK and NF-κB activation caused by RANKL was consistently reduced by MT3 deletion by both shRNAs, evidenced by lower levels of phospho-JNK and phospho-IκB (Fig
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This means that the treatment of vitiligo with ritlecitinib has been reliably validated at the transcriptional and protein levels, but its effect on stable vitiligo is more significant (NCT03715829)
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