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This guideline was widely recommended in Germany (Herrmann and Obeid, 2008) for the diagnosis of vitamin B 12 deficiency in risk groups including infants, unexplained anemia, unexplained neuropsychiatric symptoms, gastrointestinal conditions including stomatitis, anorexia and diarrhea, the elderly, vegetarians and individuals with gastrointestinal diseases such as ilium resection, chronic atrophic gastritis, Crohn's disease and Helicobacter pylori infection and individuals under treatment with proton-pump inhibitors (Herrmann and Obeid, 2008
