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Skin mast cells carry MRGPRX2, a receptor that fires on cationic, aromatic ("cationic amphiphilic") molecules and releases histamine — redness, swelling, the classic wheal.⁴ ⁵ It is confirmed for SS-31, which activates the receptor well below its injection concentration

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Primary applications focus on skin rejuvenation and surface wound healing, distinct from BPC-157’s deep tissue focus