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When a large number of substrates (receptors) are present, such that the total concentration of phosphorylated ( Z p ) and un-phosphorylated receptors ( Z ) is greater than K o and P o , i.e., Z tot ≫ K o , P o with Z tot = [ Z ] + [ Z p ], we can assume that the system is in the Michaelis-Menten (MM) regime