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For example, the Human Reference Gut Microbiome (HRGM) catalog indicates that Actinobacteriota are more prone to lacking BCAA synthesis ability, often accompanied by the loss of genes for most enzymes required for the biosynthesis of corresponding AAs

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Using data from methylation databases, we selected 18,293 CpGs presenting correlated methylation levels between blood and brain (bb-CpGs) and compare their methylation level between blood samples from patients with neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease, Multiple Sclerosis, and X Fragile Syndrome) and healthy controls