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however, preclinical evidence showed that this compound could positively affect RA via the reduced expression of β3 integrin, cathepsin K [208] and RANKL [209,210], reduce the number of Th17 cells [211], suppress MAPK or the NF-κB pathway, and alleviate bone degradation in the rodent models of CIA [212,213]
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10.1002/anie.201605509
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