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In another study, melatonin reduced high glucose-induced ER stress and autophagy in RT4-D6P2T rat Schwann cells (124)

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One proposed research model describes the following sequence of biological events: Alterations in the gut microbiome Changes in intestinal barrier function Movement of microbial metabolites into the bloodstream Biological responses involving immune and neurological signalling Investigation of potential effects on mitochondrial function and neuronal biology Researchers continue to study whether interactions between gastrointestinal function, immune signalling, metabolism, and neurological development may contribute to ASD in some individuals