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Acetate, from whatever source, is converted to acetyl-CoA by ATP-dependent acetyl-CoA synthetases (AceCS: encoded by acyl-CoA synthetase short-chain family member genes: ACSS) by the following reaction: ATP + acetate + CoA ↔ AMP + PP i + acetyl-CoA Humans express cytosolic/nuclear and mitochondrial acetyl-CoA synthetases, encoded by the ACSS2 and ACSS1 genes, respectively

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IV therapy complements a healthy lifestyle but does not replace balanced nutrition or regular supplementation