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In two phase III clinical trials, PHOENIX 1 and PHOENIX 2, the PASI 75 response rates were 66.7% and 67.1% at 12 weeks after the use of ustekinumab at 45 mg and 66.4% and 75.7% at 12 weeks after the use of ustekinumab at 90 mg (both doses were administered at week 0, week 4, and once every 12 weeks thereafter)

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The free radicals generated causes damage to mitochondrial DNA (mt DNA) and nuclear DNA (n DNA) which in turn aggravates mitochondrial damage [34]