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15 While rasburicase use is contraindicated in patients with G6PD deficiency, the acute risk of morbidity and mortality associated with untreated TLS creates a clinical dilemma
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It should be pointed out, however, that while PVPA is a simple, reproducible method alternative to diffusion cell testing, it provides no insight into the mechanism of liposome action, as the content of the vesicles in the acceptor compartment is unknown [80]
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