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Due to these limitations, Gln metabolism imaging technology primarily focuses on animal models or small-scale clinical trials, and there is a lack of large-scale population data ( 4.2 Targeting Gln metabolism to inhibit tumor proliferation 4.2.1 Inhibition of Gln uptake Tumor survival and proliferation are heavily dependent on Gln, a hydrophilic amino acid that must be transported into tumor cells by transmembrane proteins, such as SLC1A5, SLC6A14, and SLC38A1/2