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Therapeutic approaches: effects of ESA administration in anemia The administration of EPO or ESAs is a common therapeutic approach applied to stimulate and support erythropoiesis, particularly in patients with anemia associated with end-stage renal disease (21), patients with nonmyeloid cancer on chemotherapy, patients with HIV treated with zidovudine (58), or patients undergoing an elective, noncardiac nonvascular surgery to reduce the need for allogeneic blood transfusions (55)

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However, this scenario is still incomplete and further research is needed to develop diagnostic assays based on methylated patterns, such as RNA and phosphorylation profiles