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The effect of enzyme activation is particularly noticeable when opioid intoxication occurs

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Common POTS Symptoms Rapid heart rate (tachycardia) upon standing Dizziness, lightheadedness, and presyncope (feeling like you’re about to faint) Actual fainting (syncope) in some patients Severe fatigue that doesn’t improve with rest Brain fog — difficulty concentrating, word-finding problems, feeling “spacy” Exercise intolerance Nausea, bloating, and gastroparesis (delayed stomach emptying) Temperature dysregulation — overheating easily, cold extremities Blood pooling in the legs (visible mottling or purplish discoloration) Headaches, often daily Sleep disturbances despite exhaustion Chest pain and palpitations What Causes POTS