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The first involves the aberrant activation of SHP-1, resulting in reduced activation of MAP kinase signaling upstream of p47 phox phosphorylation, and the second involves the activation of Epac (the exchange protein directly activated by cAMP), which promotes inhibition of PLC through an unknown mechanism (Cerny et al., 2017)
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Selenium and GPx-1 overexpression protect mammalian cells against UV-induced DNA damage
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