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For X(PC), we demonstrated that this cell death is driven by the direct activation of caspase-1 in SUP-B15 cells, successfully mimicking canonical pyroptosis

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Mitochondrial Glutathione Reductase Mitochondrial glutathione reductase, while representing a smaller fraction (approximately 10-15%) of total cellular GR activity, fulfills a critical protective function within the mitochondria—the primary site of reactive oxygen species generation in cells