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Its neuropathological hallmarks include the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNc) and the aggregation of α-synuclein (α-syn) into Lewy bodies (LBs), which gradually spread to other central nervous system regions and peripheral tissues

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Bisphenol-A treatment induces the expression of the regulator GSK-3β (glycogen synthase kinase 3 β) in the hippocampus and SVZ, consequently reducing the ratio of phospho-GSK-3β/GSK-3β and enhancing the phospho-β-catenin/β-catenin one