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4.2 nhr-49 is required for lifespan extension in several long-lived contexts 4.2.1 nhr-49 is a key effector in the long-lived glp-1 mutant Besides its role in maintaining lifespan in wild-type worms, nhr-49 is required to extend lifespan in many long-lived contexts, including genetic mutants and dietary conditions (Figure 2)

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