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Nilsson et al., 2012), and SHMT2 can be co-induced by c-Myc and HIF1α to maintain NADPH production and redox balance in neuroblastoma and breast cancer cells (Ye et al., 2014)

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In contrast, for a high-extraction (non-restrictively cleared) drug, where h ≈ Q H , clearance is independent of protein binding

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