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These results indicate that magnesium is necessary for post-insulin receptor activation effects involving GLUT4-mediated uptake of glucose ( Additional research focusing on type 2 diabetic rat models, consisting of magnesium supplementation, showed that magnesium supplementation increases the protein expression of insulin receptors and GLUT4 in skeletal muscle and adipose tissue primarily through improved insulin-signaling efficiency and enhanced activation of downstream pathways such as PI3K/Akt
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