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Endoscopic mucosal dissection is the main treatment for early GC ( Angiogenesis is the formation of blood vessels form existing ones and it is also the basis of tumor proliferation, invasion, and metastasis in advanced GC ( In this review, in order to provide more personalized treatment plans for GC patients and provide a reliable theoretical basis for the treatment of GC with anti-angiogenic drugs, we systematically expounded the mechanism of angiogenesis on GC and summarized the results of registered clinical trials of anti-angiogenic targeted drugs for GC, as well as the response biomarkers of these drugs