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Considering c-MET in aspects of cell signaling network through cross-talking with EGFR, VEGFR-2 and other signaling molecules, it is necessary to develop antibodies that are able to inhibit simultaneously two signaling cascades to achieve maximal therapeutic activity [77, 119]
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Drug interaction databases flag moderate concern for serotonin syndrome risk if either medication is combined with certain antidepressants, though this risk is lower with tirzepatide than with phentermine alone
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