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First, homocysteine combines with serine forming cystathionine by cystathionine beta synthase (CBS), then, cystathionine is hydrolyzed into cysteine and α-ketobutyrate by cystathionine γ-lyase (CTH) Human CBS is expressed in the liver, kidneys, muscle brain and ovary, and during early embryogenesis in the neural and cardiac systems [20]
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