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Previous AngIV analogs, while showing promise in animal models of dementia, were hindered by poor metabolic stability indicated by a short half-life, and an inability to cross the BBB due to their peptide nature

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(5) K P Lesch 1, E Widerlöv, R Ekman, G Laux, et al (1988) Delta sleep-inducing peptide response to human corticotropin-releasing hormone (CRH) in major depressive disorder